Surgical Technique Spots Cancer Invasion with Fluorescence

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Surgical Technique Spots Cancer Invasion with Fluorescence

Postby patoco » Sun Jan 13, 2013 9:43 am

Surgical Technique Spots Cancer Invasion with Fluorescence


Newswise - One of the greatest challenges faced by cancer surgeons is to
know exactly which tissue to remove, or not, while the patient is under
anesthesia. A team of surgeons and scientists at University of California,
San Diego School of Medicine have developed a new technique that will allow
surgeons to identify during surgery which lymph nodes are cancerous so that
healthy tissue can be saved. The findings will be published in the January
15 print edition of Cancer Research.

"This research is significant because it shows real-time intraoperative
detection of cancer metastases in mice," said Quyen T. Nguyen, MD, PhD,
associate professor of Head and Neck Surgery at UC San Diego School of
Medicine. "In the future, surgeons will be better able to detect and stage
cancer that has spread to the patient's lymph nodes using molecules that
were designed and developed at UC San Diego."

Lymph nodes, located throughout the body, serve as filters that contain
immune cells to fight infection and clean the blood. When cancer cells break
away from a tumor, the cells can travel through the lymph system and hide in
these tiny organs. Surgeons remove the nodes to determine if a cancer has
spread. However, human nodes, only half a centimeter in size, are difficult
to discern among the surrounding tissue during surgery. Furthermore, even
when surgeons are able to map the location of the nodes, there is no current
technique that indicates whether or not the lymph nodes contain cancer,
requiring removal of more lymph nodes than necessary.

"With molecular-targeted imaging, surgeons can avoid unnecessary removal of
healthy lymph nodes which is better long-term for patients," said Nguyen,
director of the facial nerve clinic at UC San Diego Health System. "The
range of the surgeon's visual field is greatly enhanced by a molecular tool
that can help achieve accurate surgical margins and detection of metastases
so that no tumor is left behind."

The fluorescently labeled molecules, known as ratiometric activatable
cell-penetrating peptides (RACPP), are injectable. When used in mouse
models, surgeons could see where the cancer had spread with high sensitivity
and specificity even when the metastatic sites were only a few millimeters
in size.

This form of instant pathology is an improvement over traditional sentinel
node mapping, whereby only the location of the lymph node is detected
without gleaning any information on actual cancer involvement.

Current methods for managing prostate cancer and neck squamous cell
carcinoma only reveal the extent of cancer involvement after the patient has
undergone surgical removal of all susceptible lymph nodes.

This new technique will decrease OR time because the surgical team need not
wait for pathology reports, decrease time under anesthesia, and decrease
unnecessary surgery on noncancerous lymph nodes.

Nyguyen's earlier research with Nobel Prize winner Roger Tsien, PhD,
professor of pharmacology at UC San Diego School of Medicine, showed in
animal models how injectable fluorescent peptides could be used to highlight
hard-to-see peripheral nerves, allowing surgeons to avoid them when removing
or repairing other tissues.

Contributors to this research paper include Elamprakash N. Savariar, Csilla
Felsen, Nadia Nashi, Tao Jiang, Lesley G. Ellies, Paul Steinbach, and Roger
Tsien from UC San Diego.

This work was supported by the Howard Hughes Medical Institute and ICMIC
NCIP50-CA128346 career development grant, the Burroughs Wellcome Fund (CAMS)
and NIH grants 5K08EB008122 and R01 CA158448.

Released: 1/10/2013 2:00 PM EST
Source: University of California, San Diego Health Sciences

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