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glossary:cephalexin [2008/05/15 07:34]
Pat O'Connor created
glossary:cephalexin [2012/10/16 14:40] (current)
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 +====== Cephalexin ======
 +//n// brand names: Ceporex, Keftab, Keflex; ​
 +Drug class: first-generation cephalosporin; ​
 +Action: inhibits bacterial [[cell]] wall synthesis, rendering cell wall osmotically unstable; ​
 +Uses: removal of [[gram-negative bacteria]] (bacilli) from the upper and lower respiratory tracts, urinary tract, and [[skin]]; treatment of bone infections and otitis media.
 +A beta-lactam,​ first-generation cephalosporin [[antibiotic]] with bactericidal activity. Cephalexin binds to and inactivates [[penicillin]]-binding [[protein]]s (PBP) located on the inner [[membrane]] of the bacterial [[cell]] wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins,​ cephalexin is more active against [[gram-positive bacteria]] and less active against [[gram-negative bacteria]] (organisms).
glossary/cephalexin.txt · Last modified: 2012/10/16 14:40 (external edit)