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glossary:multiple_myeloma [2008/05/06 14:33]
glossary:multiple_myeloma [2012/10/16 14:40] (current)
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|+||Multiple myeloma (also known as myeloma or plasma cell myeloma) is a progressive hematologic ([[blood]]) [[disease]]. It is a [[cancer]] of the plasma cell, an important part of the [[immune system]] that produces immunoglobulins (antibodies) to help fight infection and disease. Multiple myeloma is characterized by excessive numbers of abnormal [[plasma cells]] in the [[bone marrow]] and overproduction of intact monoclonal immunoglobulin (IgG, IgA, IgD, or IgE) or Bence-Jones protein (free monoclonal κ and λ light chains). Hypercalcemia, anemia, renal damage, increased susceptibility to bacterial infection, and impaired production of normal [[immunoglobulin]] are common clinical manifestations of multiple myeloma. It is often also characterized by diffuse osteoporosis, usually in the pelvis, spine, ribs, and skull. |
|+||Cells destined to become immune cells, like all blood cells, arise in the bone marrow from [[stem cell]]s (see figure). Some stem cells develop into the small [[white blood cells]] called [[lymphocytes]]. The two major classes of lymphocytes are B cells (B lymphocytes) and [[T cell]]s (T lymphocytes). Plasma cells develop from [[B cell]]s. |
|+||See: [[http://www.multiplemyeloma.org/about_myeloma/|Multiple Myeloma Research Foundation]] |