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glossary:nephropathy [2012/10/16 14:40] (current)
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|+||Any [[kidney]] [[disease]]. For example, there is diabetic nephropathy, gouty nephropathy, HIV-associated nephropathy, ischemic nephropathy, sickle cell nephropathy,and so on. From the Greek "nephros" (kidney) + "pathos" (disease).|
|+||**Diabetic nephropathy**: The kidney disease associated with long-standing [[diabetes]]. Diabetic nephropathy is also called Kimmelstiel-Wilson disease (or Kimmelstiel-Wilson syndrome) or intercapillary glomerulonephritis.|
|+||Diabetic nephropathy typically affects the network of tiny blood vessels (the microvasculature) in the glomerulus, a key structure in the kidney composed of [[capillary]] [[blood vessels]]. The glomerulus is critically necessary for the filtration of the [[blood]]. Features of diabetic nephropathy include the [[http://www.lymphedemapeople.com/thesite/edema_nephrotic_syndrome.htm|nephrotic syndrome]] with excessive filtration of [[protein]] into the urine ([[proteinuria]]), high [[blood pressure]] ([[hypertension]]), and progressively impaired kidney function. When it is severe, diabetic nephropathy leads to kidney failure, end-stage renal disease, and the need for chronic dialysis or a kidney transplant.|
|+||The name Kimmelstiel-Wilson disease is often used. It honors Paul Kimmelstiel (1900-70), a German-born pathologist in the US, and Clifford Wilson (1906-), an English physician.|