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glossary:whipple_s_disease [2012/10/16 14:40] (current)
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|+||(1) A form of intestinal malabsorption (an inability to absorb [[nutrient]]s from the intestine) described in 1907 by the pathologist and Nobel laureate George H. Whipple in a medical missionary who first developed arthritis and then weight loss, cough, fever, diarrhea, hypotension (low [[blood_pressure]]), abdominal [[swelling]], increased [[skin]] pigmentation, and severe [[anemia]]. |
|+||The disease has been discovered to be due to a previously unknown type of [[bacteria]], now named Tropheryma whippelii, which was reported in the year 2000 to have been grown in the laboratory, opening the way for the development of a simple blood test to diagnose the disease. It is treated with [[antibiotic]]s. Some patients relapse and need long-term, even life-long, treatment.|
|+||Common Misspellings: whipple diease, whipple desease |
|+||(2) Whipple's disease is a rare infectious disorder that can affect many areas of the body, including the gastrointestinal and central nervous systems. Caused by the [[bacteria]] Tropheryma whipplei, it is typically diagnosed from malabsorption symptoms such as diarrhea and weight loss. If the central nervous system is infected, Whipple's [[disease]] can cause impairment of mental faculties and lead to dementia. It can be treated successfully with [[antibiotic]] therapy, but up to a third of patients suffer relapse.|
|+||Historically, Whipple's disease has been considered an gastro-intestinal disorder, however, in the 1960s it was realized that other organs could be involved, with or without intestinal [[infection]]. It is now considered a systemic infection with a wide range of possible symptoms.|